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CD112 (Nectin-2) Mouse anti-Human, APC, Clone: R2.477, eBioscience™

Mouse Monoclonal Antibody

$158.05 - $419.05

Specifications

Antigen CD112 (Nectin-2)
Clone R2.477
Host Species Mouse
Gene Alias PVRL2, Nectin-2, PRR2
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123069

 
affymetrix
17112841
25 tests Each for $158.05

501123070

 
affymetrix
17112842
100 tests Each for $419.05
Description & Specifications

Specifications

Antigen CD112 (Nectin-2)
Clone R2.477
Host Species Mouse
Gene Alias PVRL2, Nectin-2, PRR2
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate APC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.25μg)/test

This R2.477 monoclonal antibody reacts with human CD112 (also known as Nectin-2 or Poliovirus Receptor Related 2), a 60-65kDa immunoglobulin-like transmembrane cell adhesion molecule. This cell surface molecule is expressed on hematopoietic cells, endothelial, epithelial, as well as tumor cell lines such as Jurkat, U937, and MCF7. CD112 is a ligand for DNAM-1 (CD226), a leukocyte adhesion molecule expressed on natural killer (NK) cells. Interaction between CD112 and DNAM-1 promotes NK cytotoxic activity, leading to tumor cell lysis. In addition to its role in tumor suppression, CD112 plays a cooperative role in cell-cell adhesion, particularly in the formation of adherens junctions between neighboring epithelial cells and fibroblasts. CD112 can form homophilic and heterophilic interactions to regulate contact inhibition of cell movement and proliferation. Finally, CD112 has been reported to be a receptor for herpesvirus entry into cells.

This monoclonal antibody has been reported to block cell adhesion and herpesvirus entry.