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CD101 Mouse anti-Human, Clone: BB27, eBioscience™

Mouse Monoclonal Antibody

$143.55 - $288.55

Specifications

Antigen CD101
Clone BB27
Host Species Mouse
Gene Alias V7 antigen, IGSF 2, IGSF-2
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5012782

 
affymetrix
14-1019-80
25μg Each for $143.55

5012783

 
affymetrix
14101982
100μg Each for $288.55
Description & Specifications

Specifications

Antigen CD101
Clone BB27
Host Species Mouse
Gene Alias V7 antigen, IGSF 2, IGSF-2
Species Reactivity Human
Applications Flow Cytometry
Applications Immunohistochemistry
Applications Immunoprecipitation
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody BB27 reacts to human CD101 also known as V7 antigen, a member of the Ig superfamily. CD101 is a disulfide linked homodimer of unknown function. Expression of CD101 is found on monocytes, granulocytes and dendritic cells (Langerhan-like cells HLA-DR, CD1a, CD1c). In addition expression on T lymphocytes is important for cell activation. CD101+ CD28+ cells are very responsive to CD28 signaling. In combination with anti-CD28 or suboptimal levels of anti-CD3, anti-CD101 can increase proliferation thereby suggesting an activating role. The monoclonal antibody BB27 has been shown to inhibit the T cell reactivity in allogeneic and antigen-specific mixed DC-T cell cultures. Recently it has been demonstrated that mouse CD101 is found on a subpopulation of regulatory T cells (CD4, CD25, Foxp3 positive) that have high suppressor activity. Expression of CD101 on human PBMCs shows staining of about 30% of the Foxp3 positive cells. Studies have not confirmed higher suppressor activity in the human CD101 population.