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CD101 Mouse anti-Human, Clone: BB27, eBioscience™

Mouse Monoclonal Antibody

$130.68 - $262.68

Specifications

Antigen CD101
Clone BB27
Host Species Murine
Gene Alias V7 antigen, IGSF 2, IGSF-2
Applications Flow Cytometry,Immunohistochemistry,Immunoprecipitation
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5012782 Life Technologies
LS14101980
25μg Each for $130.68
5012783 Life Technologies
LS14101982
100μg Each for $262.68
Specifications

Description

The monoclonal antibody BB27 reacts to human CD101 also known as V7 antigen, a member of the Ig superfamily. CD101 is a disulfide linked homodimer of unknown function. Expression of CD101 is found on monocytes, granulocytes and dendritic cells (Langerhan-like cells HLA-DR, CD1a, CD1c). In addition expression on T lymphocytes is important for cell activation. CD101+ CD28+ cells are very responsive to CD28 signaling. In combination with anti-CD28 or suboptimal levels of anti-CD3, anti-CD101 can increase proliferation thereby suggesting an activating role. The monoclonal antibody BB27 has been shown to inhibit the T cell reactivity in allogeneic and antigen-specific mixed DC-T cell cultures. Recently it has been demonstrated that mouse CD101 is found on a subpopulation of regulatory T cells (CD4, CD25, Foxp3 positive) that have high suppressor activity. Expression of CD101 on human PBMCs shows staining of about 30% of the Foxp3 positive cells. Studies have not confirmed higher suppressor activity in the human CD101 population.
Description & Specifications

Specifications

CD101
Murine
Flow Cytometry,Immunohistochemistry,Immunoprecipitation
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL
BB27
V7 antigen, IGSF 2, IGSF-2
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer