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CCL8 (MCP-2) Mouse anti-Human, eFluor 660, Clone: DWZEE, eBioscience™

Mouse Monoclonal Antibody

$158.05 - $404.55

Specifications

Antigen CCL8 (MCP-2)
Clone DWZEE
Host Species Mouse
Gene Alias CC Chemokine 8, Monocyte Chemotactic Protein 2, MCP-2
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501124549

 
affymetrix
50978941
25 tests Each for $158.05

501124550

 
affymetrix
50978942
100 tests Each for $404.55
Description & Specifications

Specifications

Antigen CCL8 (MCP-2)
Clone DWZEE
Host Species Mouse
Gene Alias CC Chemokine 8, Monocyte Chemotactic Protein 2, MCP-2
Species Reactivity Human
Applications Flow Cytometry
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate eFluor 660
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.125μg)/test

This DWZEE monoclonal antibody reacts with human CCL8. CCL8, also known as MCP-2 (Monocyte Chemotactic Protein 2), is a member of the CC- subfamily of chemokines and is most closely related to CCL2 (MCP-1) and CCL7 (MCP-3). They are secreted by a variety of cell types in response to inflammatory stimuli and play critical roles in the recruitment of leukocytes to areas of inflammation. While all three MCP proteins are potent chemoattractants of monocytes and T cells, CCL7 appears to have the broadest range of activity, as it has also been demonstrated to attract activated NK cells, eosinophils, basophils, and neutrophils. CCL8 has also been demonstrated to attract NK cells, eosinophils, and basophils, but requires higher concentrations to do so. CCL8 signals via the g protein-coupled receptor CCR5, which is shared with other CC-chemokines. CCR5 is the primary co-receptor for HIV entry, which the virus binds through the gp120 envelope protein. All CCR5 ligands demonstrate potent inhibition of virus entry into the cell, both through steric hindrance of gp120-CCR5 interaction, and ligand-mediated receptor internalization.