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CCL4 (MIP-1 beta) Mouse anti-Human, APC, Clone: FL34Z3L, eBioscience™

Mouse Monoclonal Antibody

$158.05 - $404.55

Specifications

Antigen CCL4 (MIP-1 beta)
Clone FL34Z3L
Host Species Mouse
Gene Alias C-C Motif Chemokine 4, Macrophage Inflammatory Protein 1 beta
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123194

 
affymetrix
17754042
100 tests Each for $404.55

501123193

 
affymetrix
17754041
25 tests Each for $158.05
Description & Specifications

Specifications

Antigen CCL4 (MIP-1 beta)
Clone FL34Z3L
Host Species Mouse
Gene Alias C-C Motif Chemokine 4, Macrophage Inflammatory Protein 1 beta
Species Reactivity Human
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate APC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.06μg)/test

This FL34Z3L monoclonal antibody reacts with human CCL4. CCL4, also known as MIP-1 beta (Macrophage Inflammatory Protein 1 beta), is a member of the CC- subfamily of chemokines and is most closely related to CCL3, or MIP-1 alpha. These proteins play critical roles in the recruitment of leukocytes to the site of inflammation. While both CCL3 and CCL4 are chemoattractant for monocytes, macrophages, and dendritic cells, CCL4 preferentially attracts CD4+ T cells, while CD8+ T cells are more responsive to CCL3. In addition to its chemotactic functions, CCL4 induces the release of proinflammatory cytokine, mast cells degranulation, and NK cell activation.

CCL4 signaling is mediated by the G protein-coupled receptors CCR1, CCR4, and CCR5, which are shared with CCL3 and CCL5 (RANTES). CCR5 is the primary co-receptor for HIV entry, which the virus binds through the gp120 envelope protein. All CCR5 ligands demonstrate potent inhibition of virus entry into the cell, both through steric hindrance of gp120-CCR5 interaction, and ligand-mediated receptor internalization.