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CCL3 (MIP-1 alpha) Rat anti-Mouse, eFluor 660, Clone: DNT3CC, eBioscience™

Rat Monoclonal Antibody

$172.55 - $419.05

Specifications

Antigen CCL3 (MIP-1 alpha)
Clone DNT3CC
Host Species Rat
Gene Alias C-C Motif Chemokine 3, Macrophage Inflammatory Protein 1-alpha
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501124464

 
affymetrix
50753280
25μg Each for $172.55

501124465

 
affymetrix
50753282
100μg Each for $419.05
Description & Specifications

Specifications

Antigen CCL3 (MIP-1 alpha)
Clone DNT3CC
Host Species Rat
Gene Alias C-C Motif Chemokine 3, Macrophage Inflammatory Protein 1-alpha
Species Reactivity Mouse
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate eFluor 660
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

This DNT3CC monoclonal antibody reacts with mouse CCL3. CCL3, also known as MIP-1 alpha (Macrophage Inflammatory Protein 1 alpha), is a member of the CC- subfamily of chemokines and is most closely related to CCL4, or MIP-1 beta. These proteins play critical roles in the recruitment of leukocytes to the site of inflammation. While both CCL3 and CCL4 will attract monocytes, macrophages, and dendritic cells, CCL3 preferentially attracts CD8+ T cells, while CD4+ T cells are more responsive to CCL4. In addition to its chemotactic functions, CCL3 induces inflammatory cytokine secretion, mast cell degranulation, and NK cell activation. It has also been reported to inhibit hematopoetic stem cell proliferation and may be responsible for the maintenance of these cells in a quiescent state. CCL3 signaling is mediated by the G protein-coupled receptors CCR1, CCR4, and CCR5, which are shared with CCL4 and CCL5 (RANTES).