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Thermo Scientific™ Lab Vision™ Caspase 9/LAP6 Ab-4, Rabbit Polyclonal Antibody


Obtain accurate, reproducible results in immunohistochemistry, western blotting, and immunoprecipitation experiments.

Manufacturer: thermo scientific™ lab vision™  RB1205P1ABX

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Catalog No. RB1205P1ABX

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Description & Specifications

Specifications

Antigen Caspase 9/LAP6 Ab-4
Applications Immunoprecipitation
Applications Western Blotting
Classification Polyclonal
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Bovine
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Format Concentrated
Formulation Ab without BSA/Azide (Frozen)
Host Species Rabbit
Immunogen Recombinant protein encoding aa 1-134 of human caspase 9
Isotype IgG
Quantity 500μL
Regulatory Status RUO
Research Discipline Apoptosis
Type Primary
Monoclonal or Polyclonal Polyclonal
Target Species Bovine
Target Species Human
Target Species Murine
Target Species Rat

Obtain accurate, reproducible results in immunohistochemistry, western blotting and immunoprecipitation experiments with Thermo Scientific™ Caspase 9/LAP6 Ab-4, Rabbit Polyclonal Antibody. 

 

Activation of procaspase-9 by Apaf-1 in the cytochrome c/dATP-dependent pathway requires proteolytic cleavage to generate the mature caspase molecule. Deletion of the Apaf-1 WD-40 repeats makes Apaf-1 constitutively active and capable of processing procaspase-9 independent of cytochrome c and ATP. Apaf-1-mediated processing of procaspase-9 occurs at Asp-315 by an intrinsic autocatalytic activity of procaspase-9 itself. Apaf-1 can form oligomers and may facilitate procaspase-9 autoactivation by oligomerizing its precursor molecules. Once activated, caspase-9 can initiate a caspase cascade involving the downstream executioners caspase-3, -6, and -7.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human, Mouse, Rat, Cow and Sheep. Others not tested.

Epitope: aa 1-134

Immunogen: Recombinant protein encoding aa 1-134 of human caspase 9

Molecular Weight: 46-48 kDa

Positive Control: Jurkat cells, Tonsil

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunoprecipitation (Denatured verified)

Note:

USA: RUO; Int'l: RUO