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Caspase 8 Rat anti-Human, Clone: 1H10, eBioscience™

Rat Monoclonal Antibody

$130.68 - $302.28

Specifications

Antigen Caspase 8
Clone 1H10
Host Species Rat
Gene Alias Caspase8
Applications Western Blot
View More Specs

Disclaimers:

For Research Use Only.



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Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5013892 Life Technologies
LS14993480
25μg Each for $130.68
5013893 Life Technologies
LS14993482
100μg Each for $302.28
Specifications

Description

The monoclonal antibody 1H10 recognizes human Caspase-8 also known as FLICE and MACH, a member of the cysteine-requiring aspartate protease family. Caspase-8 is an upstream caspase responsible for Fas and TNF-α mediated apoptosis. After activation of the Fas or TNF receptors by their ligands, the adaptor molecule FADD binds to the receptor and recruits caspase-8 to the membrane. The formation of this complex induces the cleavage and activation of caspase-8. The active form of caspase-8, made of a heterotetramer of p18 and p10, is released in the cytoplasm and activates downstream apoptotic proteases (caspase-3, -4, -6, -7, -9 and -10). Several (> 8) isoforms have been identified: 3 different pro-forms called Caspase-8a (55kDA), Caspase-8b (53kDa), and Caspase-8L which is procaspase-8 with an additional N-terminal extension of 59 aa.
The 1H10 antibody recognizes the p55 and p53 proforms in addition to the p43 and p18 cleaved forms. Under reducing conditions, an additional band (possibly non-specific) around 35kDa may be present. Under nonreducing conditions, this band is absent.
Description & Specifications

Specifications

Caspase 8
Rat
Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL
1H10
Caspase8
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer