Epredia™ Lab Vision™ Caspase 3 (CPP32) Ab-3 Mouse Monoclonal Antibody, 200μg/mL, BSA and azide

Description

Caspase 3 is ubiquitously expressed and like other caspases is synthesized as an inactive (32kDa) proenzyme. Upon activation, Caspase 3 is cleaved at Asp28-Ser29 and Asp175-Ser176 thereby generating two subunits of 17kDa and 12kDa, respectively. Recent studies have implicated that Caspase 3 is associated with the induction of apoptosis. Activation of Caspase 3 occurs in response to a variety of apoptotic inducers including Fas-mediated apoptosis.

Host Species: Mouse

Clone: 3CSP03; same as 4.1.18

Isotype: IgG2a

Species Reactivity: Human. Others not tested.

Epitope: Not determined

Immunogen: Recombinant full-length human Caspase 3 protein

Molecular Weight: 32 kDa

Positive Control: Jurkat cells, Tonsil and appendix

Cellular Localization: Predominantly Cytoplasmic with some nuclear staining

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Western Blotting
• Immunoprecipitation (Native verified)

Note:

USA: RUO; Int'l: RUO