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Caspase 11 Rat anti-Mouse, Clone: 17D9, eBioscience™

Rat Monoclonal Antibody

$143.55 - $317.55

Specifications

Antigen Caspase 11
Clone 17D9
Host Species Rat
Gene Alias Caspase11
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013894

 
affymetrix
14-9935-80
25μg Each for $143.55

5013895

 
affymetrix
14-9935-82
100μg Each for $317.55
Description & Specifications

Specifications

Antigen Caspase 11
Clone 17D9
Host Species Rat
Gene Alias Caspase11
Species Reactivity Mouse
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody 17D9 recognizes mouse Caspase-11, a cysteine protease that plays a role in apoptosis and inflammation. Caspase-11 exists as a 43kDa and 38kDa pro-caspase form and a 30 and 10kDa active form. The 17D9 antibody recognizes p43, p38 and p30 forms. Caspase-11 is an upstream protease that activates other caspases, such as caspase-3, -7 and -1, which in turn activate IL-1β. Under Caspase-11-deficient conditions, cells are unable to process or secrete IL-1β in response to stimuli and show defects in motility, which are due to disruption of its interaction with Aip1, an actin binding protein. Caspase-11 is homologous to human Caspase-4 (around 60%). Unlike other caspases which tend to be constitutively expressed, caspase-11 is upregulated by LPS treatment in macrophages, lymphocytes and hepatocytes.