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Caspase 11 Rat anti-Mouse, Clone: 17D9, eBioscience™

Rat Monoclonal Antibody

$143.55 - $317.55

Specifications

Antigen Caspase 11
Clone 17D9
Host Species Rat
Gene Alias Caspase11
Species Reactivity Mouse
View More Specs

Disclaimers:

For Research Use Only.



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Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5013894 Life Technologies
LS14993580
25μg Each for $143.55
5013895 Life Technologies
LS14993582
100μg Each for $317.55
Specifications

Description

The monoclonal antibody 17D9 recognizes mouse Caspase-11, a cysteine protease that plays a role in apoptosis and inflammation. Caspase-11 exists as a 43kDa and 38kDa pro-caspase form and a 30 and 10kDa active form. The 17D9 antibody recognizes p43, p38 and p30 forms. Caspase-11 is an upstream protease that activates other caspases, such as caspase-3, -7 and -1, which in turn activate IL-1β. Under Caspase-11-deficient conditions, cells are unable to process or secrete IL-1β in response to stimuli and show defects in motility, which are due to disruption of its interaction with Aip1, an actin binding protein. Caspase-11 is homologous to human Caspase-4 (around 60%). Unlike other caspases which tend to be constitutively expressed, caspase-11 is upregulated by LPS treatment in macrophages, lymphocytes and hepatocytes.
Description & Specifications

Specifications

Caspase 11
Rat
Mouse
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
17D9
Caspase11
Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL