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Thermo Scientific™ Lab Vision™ Cadherin-P Ab-1, Mouse Monoclonal Antibody


Obtain accurate, reproducible results in immunohistochemistry experiments with Thermo Scientific™ Cadherin-P Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS1741R7

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Catalog No. MS1741R7

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Description & Specifications

Specifications

Antigen Cadherin-P/P-cadherin Ab-1
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 56C1
Conjugate Unlabeled
Cross Reactivity Human
Format Prediluted
Host Species Mouse
Immunogen Recombinant protein corresponding to extracellular domain of human P-cadherin
Isotype IgG1
Quantity 7mL
Regulatory Status RUO
Research Discipline Junction Protein
Type Primary

Obtain accurate, reproducible results in immunohistochemistry experiments with Thermo Scientific™ Cadherin-P Ab-1, Mouse Monoclonal Antibody.

Cadherins are calcium dependent cell adhesion molecules, which play important roles in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. They are expressed in a tissue specific manner and are required for assembly of cells into solid tissue. Individual cadherin molecules are known to cooperate with each other to form a linear cell adhesion zipper. In adhesion junctions cadherins are bound to Beta and gamma catenins which in turn bind to alpha catenin, an actin binding protein. Cadherins play important part in tumor invasion and metastasis. P-cadherin is selectively expressed in basal and parabasal layers of stratified epithelia. It may be involved in the final stages of tumor progression in epidermal carcinoma. Changes in P-cadherin expression have been implicated in breast and melanocytic tumors.

Host Species: Mouse

Clone: 56C1

Isotype: IgG1

Species Reactivity: Human. Others not known.

Epitope: External domain

Immunogen: Recombinant protein corresponding to extracellular domain of human cadherin-P

Molecular Weight: 120kDa

Positive Control: Skin

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)

Note:

USA: IVD; Int'l: IVD