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c-ErbB3/HER3 Mouse anti-Human, PerCP-eFluor 710, Clone: SGP1, eBioscience™

Mouse Monoclonal Antibody

$201.55 - $448.05

Specifications

Antigen c-ErbB3/HER3
Clone SGP1
Host Species Mouse
Species Reactivity Human
Applications Flow Cytometry
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

50245934

 
affymetrix
46655541
25 tests Each for $201.55

50245935

 
affymetrix
46655542
100 tests Each for $448.05
Description & Specifications

Specifications

Antigen c-ErbB3/HER3
Clone SGP1
Host Species Mouse
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PerCP-eFluor 710
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.125μg)/test

This SGP1 monoclonal antibody reacts with human c-ErbB3, which is also known as HER3. This epidermal growth factor (EGF) receptor family member is expressed on normal human tissues, particularly on neurons and cells of the gastrointestinal tract. c-ErbB3 is overexpressed in a variety of cancers, including breast, ovary, and gastrointestinal carcinomas. Upon binding its ligand heregulin beta-1, c-ErbB3 is activated by heterodimerization with ErbB2 or EGFR1. Dependent on PI3K signaling, c-ErbB3 mediates tumor cell invasion, intravasation, and metastasis. Expression of this cell surface receptor has been used as a prognostic marker for breast cancer.

The SGP1 antibody has been reported to stimulate anchorage-independent growth of breast cancer cell lines.