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c-ErbB3/HER3 Mouse anti-Human, PerCP-eFluor 710, Clone: SGP1, eBioscience™

Mouse Monoclonal Antibody

$183.48 - $407.88

Specifications

Antigen c-ErbB3/HER3
Clone SGP1
Host Species Murine
Species Reactivity Human
Applications Flow Cytometry
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
50245934 Life Technologies
LS46655541
25 Tests Each for $183.48
50245935 Life Technologies
LS46655542
100 Tests Each for $407.88
Specifications

Description

This SGP1 monoclonal antibody reacts with human c-ErbB3, which is also known as HER3. This epidermal growth factor (EGF) receptor family member is expressed on normal human tissues, particularly on neurons and cells of the gastrointestinal tract. c-ErbB3 is overexpressed in a variety of cancers, including breast, ovary, and gastrointestinal carcinomas. Upon binding its ligand heregulin beta-1, c-ErbB3 is activated by heterodimerization with ErbB2 or EGFR1. Dependent on PI3K signaling, c-ErbB3 mediates tumor cell invasion, intravasation, and metastasis. Expression of this cell surface receptor has been used as a prognostic marker for breast cancer.

The SGP1 antibody has been reported to stimulate anchorage-independent growth of breast cancer cell lines.
Description & Specifications

Specifications

c-ErbB3/HER3
Murine
Flow Cytometry
PerCP-eFluor 710
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
5μL (0.125μg)/test
SGP1
Human
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer