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Thermo Scientific™ Lab Vision™ c-Abl Ab-1, Mouse Monoclonal Antibody


Obtain accurate, reproducible results in immunohistochemistry, western blotting, immunofluorescence, and immunoprecipitation procedures.

Manufacturer: thermo scientific™ lab vision™  MS938P1ABX

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Catalog No. MS938P1ABX

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Description & Specifications

Specifications

Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Cross Reactivity Human
Cross Reactivity Mouse
Format Concentrated
Immunogen Recombinant Abl protein
Quantity 100µL
Antigen c-Abl Ab-1
Host Species Mouse
Isotype IgG1
Regulatory Status RUO
Clone 8E9
Formulation Ab without BSA/Azide (Frozen)
Research Discipline Signal Transduction
Type Primary
Classification Monoclonal
Concentration 1mg/mL
Conjugate Unlabeled

Obtain accurate, reproducible results in immunohistochemistry, western blotting, immunofluorescence, and immunoprecipitation procedures with Thermo Scientific™ c-Abl Ab-1, Mouse Monoclonal Antibody.

The c-Abl proto-oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome). As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.

Host Species: Mouse

Clone: 8E9

Isotype: IgG1/γ

Species Reactivity: Human and Mouse. Others not tested.

Epitope: SH2 domain

Immunogen: Recombinant Abl protein

Molecular Weight: 120kDa

Positive Control: HeLa cells or placenta

Cellular Localization: Cytoplasmic and nuclear

Ab-1 reacts with c-Abl p120 and chimeric Bcr/Abl proteins.

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation

Note:

USA: RUO; Int'l: RUO