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Thermo Scientific™ Lab Vision™ c-Abl Ab-1, Mouse Monoclonal Antibody


Obtain accurate, reproducible results in immunohistochemistry, western blotting, immunofluorescence, and immunoprecipitation procedures.

Manufacturer: thermo scientific™ lab vision™  MS938P1ABX

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Catalog No. MS938P1ABX

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Description & Specifications

Specifications

Antigen c-Abl Ab-1
Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Classification Monoclonal
Clone 8E9
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Format Concentrated
Formulation Ab without BSA/Azide (Frozen)
Host Species Mouse
Immunogen Recombinant Abl protein
Isotype IgG1
Quantity 100µL
Regulatory Status RUO
Research Discipline Signal Transduction
Type Primary

Obtain accurate, reproducible results in immunohistochemistry, western blotting, immunofluorescence, and immunoprecipitation procedures with Thermo Scientific™ c-Abl Ab-1, Mouse Monoclonal Antibody.

The c-Abl proto-oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome). As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.

Host Species: Mouse

Clone: 8E9

Isotype: IgG1/γ

Species Reactivity: Human and Mouse. Others not tested.

Epitope: SH2 domain

Immunogen: Recombinant Abl protein

Molecular Weight: 120kDa

Positive Control: HeLa cells or placenta

Cellular Localization: Cytoplasmic and nuclear

Ab-1 reacts with c-Abl p120 and chimeric Bcr/Abl proteins.

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation

Note:

USA: RUO; Int'l: RUO