Thermo Scientific™ Lab Vision™ c-Abl Ab-1, Mouse Monoclonal Antibody
Obtain accurate, reproducible results in immunohistochemistry, western blotting, immunofluorescence, and immunoprecipitation procedures.
Manufacturer: Thermo Scientific™ Lab Vision™ MS938P1ABX
Obtain accurate, reproducible results in immunohistochemistry, western blotting, immunofluorescence, and immunoprecipitation procedures with Thermo Scientific™ c-Abl Ab-1, Mouse Monoclonal Antibody.
The c-Abl proto-oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome). As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.
Host Species: Mouse
Species Reactivity: Human and Mouse. Others not tested.
Epitope: SH2 domain
Immunogen: Recombinant Abl protein
Molecular Weight: 120kDa
Positive Control: HeLa cells or placenta
Cellular Localization: Cytoplasmic and nuclear
Ab-1 reacts with c-Abl p120 and chimeric Bcr/Abl proteins.
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting
USA: RUO; Int'l: RUO
|Ab without BSA/Azide (Frozen)|
|Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blotting|
|Recombinant Abl protein|