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Thermo Scientific™ Lab Vision™ c-Abl Ab-1, Mouse Monoclonal Antibody


Obtain accurate, reproducible results in immunohistochemistry, western blotting, immunofluorescence, and immunoprecipitation procedures.

Manufacturer: thermo scientific™ lab vision™  MS938P1ABX

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Catalog No. MS938P1ABX

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Description & Specifications

Specifications

Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Cross Reactivity Human
Cross Reactivity Mouse
Quantity 100µL
Immunogen Recombinant Abl protein
Format Concentrated
Regulatory Status RUO
Clone 8E9
Host Species Mouse
Isotype IgG1
Antigen c-Abl Ab-1
Formulation Ab without BSA/Azide (Frozen)
Concentration 1mg/mL
Research Discipline Signal Transduction
Conjugate Unlabeled
Type Primary
Classification Monoclonal

Obtain accurate, reproducible results in immunohistochemistry, western blotting, immunofluorescence, and immunoprecipitation procedures with Thermo Scientific™ c-Abl Ab-1, Mouse Monoclonal Antibody.

The c-Abl proto-oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome). As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.

Host Species: Mouse

Clone: 8E9

Isotype: IgG1/γ

Species Reactivity: Human and Mouse. Others not tested.

Epitope: SH2 domain

Immunogen: Recombinant Abl protein

Molecular Weight: 120kDa

Positive Control: HeLa cells or placenta

Cellular Localization: Cytoplasmic and nuclear

Ab-1 reacts with c-Abl p120 and chimeric Bcr/Abl proteins.

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation

Note:

USA: RUO; Int'l: RUO