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Bortezomib, 98%, Thermo Scientific Chemicals
Bortezomib (CAS # 179324-69-7) is an inhibitor of protein degradation pathways.
Supplier: Thermo Scientific Chemicals J60378MB
Description
A potent, highly selective and reversible inhibitor of the 20S proteasome, Bortezomib is used as an antineoplastic agent, which controls the growth of cancer cells. It is also useful in the treatment of multiple myeloma.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Bortezomib is an antineoplastic compound derived from boronic acid
• Bortezomib reversibly inhibits the 26S proteostome that maintains cell cycle pathways related to growth and division
• Bortezomib is an inhibitor of NF-κB, a factor that is constituitively active in some cancers
Application
• Bortezomib is suitable for use in the research of multiple myeloma and lymphomas, and for use in the research of protein degradation pathways
• Bortezomib is intended for in vitro and biochemical applications
Specifications
| Bortezomib | |
| 139°C to 143°C | |
| C19H25BN4O4 | |
| 25 mg | |
| 14,1351 | |
| Soluble in chloroform,dimethyl sulfoxide,ethanol and methanol. | |
| B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O | |
| 384.243 | |
| CHEBI:52717 | |
| 99% |
| 179324-69-7 | |
| Brown to White | |
| MFCD09056737 | |
| UN3249 | |
| bortezomib, velcade, bortezomib ps-341, dpba, pyz-phe-boroleu, unii-69g8bd63pp, velcade tn, bortezomib velcade, 1r-3-methyl-1-2s-1-oxo-3-phenyl-2-pyrazinylcarbonyl amino propyl amino butyl boronic acid, 1r-3-methyl-1-2s-3-phenyl-2-pyrazine-2-carbonylamino propanoyl amino butyl boronic acid | |
| GXJABQQUPOEUTA-RDJZCZTQSA-N | |
| [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid | |
| 387447 | |
| 384.24 | |
| Powder |
Chemical Identifiers
| 179324-69-7 | |
| 384.243 | |
| GXJABQQUPOEUTA-RDJZCZTQSA-N | |
| 387447 | |
| [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid |
| C19H25BN4O4 | |
| MFCD09056737 | |
| bortezomib, velcade, bortezomib ps-341, dpba, pyz-phe-boroleu, unii-69g8bd63pp, velcade tn, bortezomib velcade, 1r-3-methyl-1-2s-1-oxo-3-phenyl-2-pyrazinylcarbonyl amino propyl amino butyl boronic acid, 1r-3-methyl-1-2s-3-phenyl-2-pyrazine-2-carbonylamino propanoyl amino butyl boronic acid | |
| CHEBI:52717 | |
| B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O |
Safety and Handling
GHS H Statement
H300-H310-H330-H372
Fatal if swallowed.
Fatal in contact with skin.
Fatal if inhaled.
Causes damage to organs through prolonged or repeated exposure.
P260-P264b-P270-P271-P280-P284-P301+P310-P302+P352-P304+P340-P310-P312-P314-P330-P361-P363-P501c
H301+H311-H330-H372
DOTInformation : Transport Hazard Class: 6.1; Packing Group: II; Proper Shipping Name: MEDICINE, SOLID, TOXIC, N.O.S.
RTECSNumber : ED7771666
TSCA : No
Recommended Storage : Store at -20°C
RUO – Research Use Only