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Blimp1 Rat anti-Mouse, PE, Clone: 5E7, eBioscience™

Rat Monoclonal Antibody

$216.05 - $535.05

Specifications

Antigen Blimp1
Clone 5.00E+07
Host Species Rat
Gene Alias Prdm1, B lymphocyte induced maturation protein 1
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122467

 
affymetrix
12985080
25μg Each for $216.05

501122468

 
affymetrix
12985082
100μg Each for $535.05
Description & Specifications

Specifications

Antigen Blimp1
Clone 5.00E+07
Host Species Rat
Gene Alias Prdm1, B lymphocyte induced maturation protein 1
Species Reactivity Mouse
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

This 5E7 monoclonal antibody recognizes mouse B lymphocyte-induced maturation protein-1 (Blimp-1), which is also known as Prdm1. Blimp-1 is a transcriptional repressor with five zinc finger domains. Blimp-1 is expressed by terminally differentiating B and T cells. Blimp-1 is also expressed by some dendritic cells, and some NK cells. This transcriptional repressor is required for B cell differentiation into plasma cells and serves as a critical antagonist of CD4+ follicular helper T cell differentiation. While Blimp-1 is not required for priming and development of T and B cell effector function, it is critical for effector cell terminal differentiation. Blimp-1 promotes effector molecule secretion while suppressing proliferation. Blimp-1 also acts as a transcriptional antagonist of Bcl-6 and inhibits genes that are related to memory cell differentiation.