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Bcl-6 Mouse anti-Human, PerCP-eFluor 710, Clone: BCL-UP, eBioscience™

Mouse Monoclonal Antibody

$216.05 - $535.05

Specifications

Antigen Bcl-6
Clone BCL-UP
Host Species Mouse
Gene Alias B-cell lymphoma 6
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

50245946

 
affymetrix
46988041
25 tests Each for $216.05

50245947

 
affymetrix
46988042
100 tests Each for $535.05
Description & Specifications

Specifications

Antigen Bcl-6
Clone BCL-UP
Host Species Mouse
Gene Alias B-cell lymphoma 6
Species Reactivity Human
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate PerCP-eFluor 710
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.03μg)/test

The monoclonal antibody BCL-UP recognizes Bcl-6, also known as B-cell lymphoma 6,which is a member of the POZ family of transcriptional repressors. Bcl-6 is expressed most abundantly in germinal center B cells, as well as in differentiating and activated B cells. This 79kDa protein is essential for germinal center B cell proliferation and survival. During B cell development, Bcl-6 plays an important role in promoting pre-B cell survival to enable the generation of a diverse B cell repertoire. Moreover, Bcl-6 is expressed constitutively in diffuse large B cell lymphomas (DLBCLs), Burkitt’s lymphoma, and non-Hodgkin’s lymphoma. Reports also suggest expression of Bcl-6 in CD4+ T follicular helper cells and memory T cells. Bcl-6 has been reported to be antagonized by Blimp-1.