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Bcl-6 Mouse anti-Human, Mouse, Clone: GI191E, eBioscience™

Mouse Monoclonal Antibody

$158.05 - $361.05

Specifications

Antigen Bcl-6
Clone GI191E
Host Species Mouse
Gene Alias B-cell lymphoma 6, Bcl6
Species Reactivity Human, Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013824

 
life technologies
LS14988780
25μg Each for $158.05

5013825

 
life technologies
LS14988782
100μg Each for $361.05
Description & Specifications

Specifications

Antigen Bcl-6
Clone GI191E
Host Species Mouse
Gene Alias B-cell lymphoma 6, Bcl6
Species Reactivity Human, Mouse
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

This GI191E monoclonal antibody reacts with mouse and human Bcl-6, which is also known as B-cell lymphoma 6. A member of the POZ family of transcriptional repressors, Bcl-6 is expressed most abundantly in germinal center B cells, as well as in differentiating and activated B cells. This 79kDa protein is essential for germinal center B cell proliferation and survival. Moreover, during B cell development, Bcl-6 plays an important role in promoting pre-B cell survival to enable the generation of a diverse B cell repertoire. Moreover, Bcl-6 is expressed constitutively in diffuse large B cell lymphomas (DLBCLs), Burkitt’s lymphoma, and non-Hodgkin’s lymphoma. Reports also suggest expression of Bcl-6 in CD4+ T follicular helper cells and memory T cells. Bcl-6 has been reported to be antagonized by Blimp-1.