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Bcl-6 Mouse anti-Human, Mouse, Clone: GI191E, eBioscience™

Mouse Monoclonal Antibody

$158.05 - $361.05

Specifications

Antigen Bcl-6
Clone GI191E
Host Species Mouse
Gene Alias B-cell lymphoma 6, Bcl6
Species Reactivity Human, Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013824

 
affymetrix
14-9887-80
25μg Each for $158.05

5013825

 
affymetrix
14988782
100μg Each for $361.05
Description & Specifications

Specifications

Antigen Bcl-6
Clone GI191E
Host Species Mouse
Gene Alias B-cell lymphoma 6, Bcl6
Species Reactivity Human, Mouse
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

This GI191E monoclonal antibody reacts with mouse and human Bcl-6, which is also known as B-cell lymphoma 6. A member of the POZ family of transcriptional repressors, Bcl-6 is expressed most abundantly in germinal center B cells, as well as in differentiating and activated B cells. This 79kDa protein is essential for germinal center B cell proliferation and survival. Moreover, during B cell development, Bcl-6 plays an important role in promoting pre-B cell survival to enable the generation of a diverse B cell repertoire. Moreover, Bcl-6 is expressed constitutively in diffuse large B cell lymphomas (DLBCLs), Burkitt’s lymphoma, and non-Hodgkin’s lymphoma. Reports also suggest expression of Bcl-6 in CD4+ T follicular helper cells and memory T cells. Bcl-6 has been reported to be antagonized by Blimp-1.