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Bcl-2 Mouse anti-Mouse, Rat, PE-Cy7, Clone: 10C4, eBioscience™

Mouse Monoclonal Antibody

$143.55 - $361.05

Specifications

Antigen Bcl-2
Clone 10C4
Host Species Mouse
Gene Alias B cell lymphoma 2
Species Reactivity Mouse, Rat
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123426

 
affymetrix
25699241
25 tests Each for $143.55

501123427

 
affymetrix
25699242
100 tests Each for $361.05
Description & Specifications

Specifications

Antigen Bcl-2
Clone 10C4
Host Species Mouse
Gene Alias B cell lymphoma 2
Species Reactivity Mouse, Rat
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate PE-Cy7
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.25μg)/test

The 10C4 monoclonal antibody reacts with mouse and rat Bcl-2, also known as B cell lymphoma 2. Bcl-2 is the founding member of the Bcl-2 family of evolutionarily-conserved proteins that regulate cell death/survival. Members of the Bcl-2 family include the pro-apoptotic proteins BAD, Bax, and Bim, and the anti-apoptotic proteins Bcl-2, Bcl-xL, and Mcl-1. Bcl-2 inhibits apoptosis by preventing the release of cytochrome c from the mitochondria. Mutation of Bcl-2 or overexpression of Bcl-2 due to chromosomal translocation has been identified as a contributing factor in numerous cancers. In developing thymocytes, Bcl-2 is expressed at high levels in CD4-CD8- double negative and in CD4+ and CD8+ single positive thymocytes; Bcl-2 expression is greatly diminished in CD4+CD8+ double positive thymocytes.