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Bcl-2 Mouse anti-Mouse, Rat, eFluor 660, Clone: 10C4, eBioscience™

Mouse Monoclonal Antibody

$130.68 - $328.68

Specifications

Antigen Bcl-2
Clone 10C4
Host Species Murine
Gene Alias B cell lymphoma 2
Species Reactivity Mouse, Rat
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501124428 Life Technologies
LS50699241
25 Tests Each for $130.68
501124429 Life Technologies
LS50699242
100 Tests Each for $328.68
Specifications

Description

The 10C4 monoclonal antibody reacts with mouse and rat Bcl-2, also known as B cell lymphoma 2. Bcl-2 is the founding member of the Bcl-2 family of evolutionarily-conserved proteins that regulate cell death/survival. Members of the Bcl-2 family include the pro-apoptotic proteins BAD, Bax, and Bim, and the anti-apoptotic proteins Bcl-2, Bcl-xL, and Mcl-1. Bcl-2 inhibits apoptosis by preventing the release of cytochrome c from the mitochondria. Mutation of Bcl-2 or overexpression of Bcl-2 due to chromosomal translocation has been identified as a contributing factor in numerous cancers. In developing thymocytes, Bcl-2 is expressed at high levels in CD4-CD8- double negative and in CD4+ and CD8+ single positive thymocytes; Bcl-2 expression is greatly diminished in CD4+CD8+ double positive thymocytes.
Description & Specifications

Specifications

Bcl-2
Murine
Mouse, Rat
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
10C4
B cell lymphoma 2
Flow Cytometry (Intracellular Staining)
eFluor 660
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
5μL (0.25μg)/test