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Tocris™ Banoxantrone dihydrochloride

Prodrug topoisomerase II inhibitor

$237.76 - $1,001.17

Specifications

Product Type Banoxantrone dihydrochloride
Inhibitors Banoxantrone dihydrochloride
Molecular Weight 517.4
Purity >98
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 Disclaimers

For Research Use Only

Products
Catalog Number Mfr. No. Quantity Price Quantity    

4219/10

 
tocris™
4219/10
10mg Each for $237.76

4219/50

 
tocris™
4219/50
50mg Each for $1,001.17
Description & Specifications

Specifications

Product Type Banoxantrone dihydrochloride
Inhibitors Banoxantrone dihydrochloride
Molecular Weight 517.4
Purity >98

Bioreductive prodrug; activated by hypoxia to yield the topoisomerase II inhibitor AQ4. Displays little to no cytotoxic activity against 60 tumor cell lines tested under oxic conditions (IC50 >100μM). Exhibits anti-tumor efficacy in vivo when combined with oxic cell cytotoxins; enhances the anti-tumor effect of cyclophosphamide (Cat. No. 4091) in a mouse tumor model.

  • Chemical Name: 1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride
  • Formula: C22H28N4O6.2HCl
  • CAS Number: 252979-56-9
  • Solubility: Soluble to 50mM in water and to 25mM in DMSO)
  • Purity: >98