Please login to your online account to display your discounted pricing

Tocris™ BAG 956

Dual PI 3-kinase and PDK1 inhibitor

$294.31 - $1,240.21

Specifications

Product Type BAG 956
Inhibitors BAG 956
Molecular Weight 427.5
Purity >99
View More Specs

 Disclaimers

For Research Use Only

Products
Catalog Number Mfr. No. Quantity Price Quantity    

360610R

 
tocris™
3606/10
10mg Each for $294.31

360650R

 
tocris™
3606/50
50mg Each for $1,240.21
Description & Specifications

Specifications

Product Type BAG 956
Inhibitors BAG 956
Molecular Weight 427.5
Purity >99

Dual PDK1 and class I PI 3-K inhibitor (IC50 values are 245, 56, 446, 35 and 117nM for PDK1 and PI 3-K p110 -α, -β, -δ, and -γ respectively). Inhibits cellular AKT phosphorylation at Thr308. Blocks cell proliferation, causing arrest in G1 phase of the cell cycle. Slows tumor progression in mouse xenograft models.

  • Chemical Name: α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile
  • Formula: C28H21N5
  • CAS Number: 853910-02-8
  • Solubility: Soluble to 40mM in DMSO and to 20mM in ethanol