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Alfa Aesar™ Bafilomycin A1, 0.1mg/mL in DMSO, sterile-filtered

$241.30 - $241.30

Chemical Identifiers

Chemical Name or Material Bafilomycin A1
CAS 88899-55-2
Name Note 0.1mg/mL in DMSO, sterile-filtered
MDL Number MFCD06795130
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Products
Catalog Number Mfr. No. Quantity Price Quantity    

AAJ67193XF

 
alfa aesar™
J67193-XF
1mL Each for $241.30
Description & Specifications

Specifications

Quantity 1mL
Chemical Name or Material Bafilomycin A1
Name Note 0.1mg/mL in DMSO, sterile-filtered
CAS 88899-55-2
Physical Form Liquid
MDL Number MFCD06795130
Health Hazard 1 Warning
Health Hazard 2 GHS H Statement
H227
Combustible liquid.
Health Hazard 3 GHS P Statement
P210-P280-P370+P378a-P403+P235-P501a
Keep away from heat/sparks/open flames/hot surfaces.
- No smoking.
Wear protective gloves/protective clothing/eye protection/face protection.
In case of fire: Use for extinction: CO2, powder or water spray.
Store in a well-ventilated place.
Keep cool.
Dispose of contents/container in accordance with local/regional/national/international regulations.
Storage Note 1 -30° to -10°C
RTECS Number RN9781000

Applications
Bafilomycin A1 is a potent and selective inhibitor of V-ATPase (vacuolar-type H+ ATPase). The compound can inhibit E1E2 ATPases from sarcoplasmic reticulum, Escherichia coli, and ox brain versus F1F0 ATPases found in bacteria and mitochondria. Some of the more bafilomycin A1 affected ATPases include Neurospora and plant vacuoles, as well as chromaffin granules. Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells.

Solubility
Soluble in methanol, ethanol (0.1 mg/ml), DMSO (0.1 mg/ml), acetone, and chloroform. Insoluble in water.

Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Safety and Handling

Warning

GHS P Statement
P210-P280-P370+P378a-P403+P235-P501a
Keep away from heat/sparks/open flames/hot surfaces.
- No smoking.
Wear protective gloves/protective clothing/eye protection/face protection.
In case of fire: Use for extinction: CO2, powder or water spray.
Store in a well-ventilated place.
Keep cool.
Dispose of contents/container in accordance with local/regional/national/international regulations.

GHS H Statement
H227
Combustible liquid.

-30° to -10°C