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Bafilomycin A1, 0.1 mg/ml in DMSO, sterile-filtered, Thermo Scientific Chemicals
Bafilomycin A1, CAS # 88899-55-2, is an inhibitor of vacuolar ATPases from Streptomyces griseus that has antibacterial, antifungal, and antineoplastic activity.
Supplier: Thermo Scientific Chemicals J67193XF
Description
Bafilomycin A1 is a potent and selective inhibitor of V-ATPase (vacuolar-type H+Â ATPase). The compound can inhibit E1E2 ATPases from sarcoplasmic reticulum, Escherichia coli, and ox brain versus F1F0 ATPases found in bacteria and mitochondria. Some of the more bafilomycin A1 affected ATPases include Neurospora and plant vacuoles, as well as chromaffin granules. Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases
• It is a macrolide antibiotic, and shows fungicide activity
Application
• Bafilomycin A1 has antibacterial, antifungal, and antineoplastic activity
• It can be immunosuppressive
• It can prevent maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes
• It is a potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase)
Specifications
| Bafilomycin A1 | |
| 0.1mg/mL in DMSO, sterile-filtered | |
| 88899-55-2 | |
| MFCD06795130 | |
| XDHNQDDQEHDUTM-XRCNURIOSA-N | |
| (3Z,5E,7S,8R,9R,11Z,15R,16S)-16-[(2R,3S,4R)-4-[(2S,4S,5R,6S)-2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one | |
| 133268469 |
| Bafilomycin A1 | |
| Liquid | |
| C35H58O9 | |
| Soluble in methanol,ethanol (0.1mg/ml),DMSO (0.1mg/ml),acetone,and chloroform. Insoluble in water. | |
| CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)O)O)O)OC)C | |
| 622.84 | |
| 1 mL |
Chemical Identifiers
| 88899-55-2 | |
| 622.84 | |
| XDHNQDDQEHDUTM-XRCNURIOSA-N | |
| (3Z,5E,7S,8R,9R,11Z,15R,16S)-16-[(2R,3S,4R)-4-[(2S,4S,5R,6S)-2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one |
| C35H58O9 | |
| MFCD06795130 | |
| 133268469 | |
| CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)O)O)O)OC)C |
Safety and Handling
GHS H Statement
H227
Combustible liquid.
P210-P280-P370+P378q-P501c
H227
RTECSNumber : RN9781000
TSCA : No
storageNote1 : -30° to -10°C
Recommended Storage : Store at -20°C
RUO – Research Use Only