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Ascomycin, 95%, Alfa Aesar™

Internal standard for LC-MS/MS testing of the immunosuppressants tacrolimus, sirolimus, and everolimus.

Manufacturer:  Thermo Fisher Scientific J66751MB

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Catalog No. AAJ66751MB



Description

Description

Applications
Ascomycin is a potent immunosuppressive agent that could be used as a potential therapeutic agent for autoimmune diseases. Ascomycin is an inhibitor of PP2. It is an internal standard for LC-MS/MS testing of the immunosuppressants tacrolimus, sirolimus, and everolimus. This Certified Spiking Solution™ is suitable for critical quantitative applications in clinical and diagnostic testing such as therapeutic drug monitoring assays to ensure patients remain within the narrow therapeutic range of these immunosuppressants.

Solubility
Soluble in DMSO at 65mg/ml; soluble in ethanol at 50mg/m; with warming. Very poorly soluble in water

Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.
Specifications

Specifications

Ascomycin
868°C
156°C to 160°C
104987-12-4
MFCD06198665
Soluble in DMSO at 65mg/mL; soluble in ethanol at 50mg/mL; with warming. Very poorly soluble in water
CCC1C=C(CC(CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC1=O)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC)C)C
5282071
790
95%
>110°C(230°F)
White
25mg
C43H69NO12
15,19-epoxy-3h-pyrido 2,1-c 1,4 oxaazacyclotricosine-1,7,20,21 4h,23h-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-8-ethyl-3-2-4-hydroxy-3-methoxycyclohexyl-1-methylethenyl-14,16-dimethoxy-4,10,12,18-tetramethyl-, 3s-3r* e 1s*,3s*,4s* ,4s*,19s*,26ar*
ZDQSOHOQTUFQEM-NURRSENYSA-N
792.02
CHEBI:29582
Powder

Chemical Identifiers

104987-12-4
792.02
ZDQSOHOQTUFQEM-NURRSENYSA-N
5282071
CCC1C=C(CC(CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC1=O)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC)C)C
C43H69NO12
MFCD06198665
15,19-epoxy-3h-pyrido 2,1-c 1,4 oxaazacyclotricosine-1,7,20,21 4h,23h-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-8-ethyl-3-2-4-hydroxy-3-methoxycyclohexyl-1-methylethenyl-14,16-dimethoxy-4,10,12,18-tetramethyl-, 3s-3r* e 1s*,3s*,4s* ,4s*,19s*,26ar*
CHEBI:29582
Safety and Handling

Safety and Handling

GHS H Statement
H302-H312-H332
Harmful if swallowed.
Harmful in contact with skin.
Harmful if inhaled.

GHS P Statement
P261-P280-P304+P340-P301+P312-P312-P501a
Avoid breathing dust/fume/gas/mist/vapors/spray.
Wear protective gloves/protective clothing/eye protection/face protection.
IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.
IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
Call a POISON CENTER or doctor/physician if you feel unwell.
Dispose of contents/container in accordance with local/regional/national/international regulations.

Warning

RTECSNumber : KD4185000

storageNote1 : −30° to −10°C

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