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APP (Amyloid Precursor Protein) Mouse, eFluor 570, Clone: 22C11, eBioscience™

Mouse Monoclonal Antibody

$172.55 - $433.55

Specifications

Antigen APP (Amyloid Precursor Protein)
Clone 22C11
Host Species Mouse
Gene Alias Alzheimer Precursor Protein A4
Species Reactivity Human, Mouse, Rat
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123647

 
affymetrix
41974980
25μg Each for $172.55

501123648

 
affymetrix
41974982
100μg Each for $433.55
Description & Specifications

Specifications

Antigen APP (Amyloid Precursor Protein)
Clone 22C11
Host Species Mouse
Gene Alias Alzheimer Precursor Protein A4
Species Reactivity Human, Mouse, Rat
Applications Immunocytochemistry
Applications Microscopy
Regulatory Status RUO
Conjugate eFluor 570
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The monoclonal antibody 22C11 recognizes human, mouse, and rat APP (Amyloid Precursor Protein). APP is expressed in high abundance in the central nervous system and has three major isoforms resulting from alternative splicing. APP plays a role in synaptic formation and repair, anterograde neuronal transport, iron export, and hormonal regulation. Secreted APP (sAPP) may have neuroprotective effects against neurotoxic insult, oxidative stress, and excitotoxicity. APP belongs to a family that contains at least two homologs, amyloid precursor-like proteins 1 and 2 (APLP1 and APLP2). Similarities between APP and APLP, especially APLP2, suggest that APLP could share and compensate for the function of APP. Proteolytic cleavage of APP results in the generation of beta amyloid, which is the primary component of senile plaques. Senile plaques are one of the major histopathologic features of Alzheimer’s disease. Abnormal regulation and processing of APP also plays a role in Down’s syndrome, early onset familial Alzheimer’s disease, cerebral hemorrhage, and arthritis.

This 22C11 antibody reacts with pre-A4 and recognizes all three isoforms of APP (immature, sAPP, and mature). This 22C11 antibody is known to cross react with APLP2.