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APP (Amyloid Precursor Protein) Mouse, Clone: 22C11, eBioscience™

Mouse Monoclonal Antibody

$146.52 - $361.68

Specifications

Antigen APP (Amyloid Precursor Protein)
Clone 22C11
Host Species Murine
Gene Alias Alzheimer Precursor Protein A4
Applications Immunocytochemistry,Microscopy
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122817 Life Technologies
LS14974980
25μg Each for $146.52
501122818 Life Technologies
LS14974982
100μg Each for $361.68
Specifications

Description

The monoclonal antibody 22C11 recognizes human, mouse, and rat APP (Amyloid Precursor Protein). APP is expressed in high abundance in the central nervous system and has three major isoforms resulting from alternative splicing. APP plays a role in synaptic formation and repair, anterograde neuronal transport, iron export, and hormonal regulation. Secreted APP (sAPP) may have neuroprotective effects against neurotoxic insult, oxidative stress, and excitotoxicity. APP belongs to a family that contains at least two homologs, amyloid precursor-like proteins 1 and 2 (APLP1 and APLP2). Similarities between APP and APLP, especially APLP2, suggest that APLP could share and compensate for the function of APP. Proteolytic cleavage of APP results in the generation of beta amyloid, which is the primary component of senile plaques. Senile plaques are one of the major histopathologic features of Alzheimer’s disease. Abnormal regulation and processing of APP also plays a role in Down’s syndrome, early onset familial Alzheimer’s disease, cerebral hemorrhage, and arthritis.

This 22C11 antibody reacts with pre-A4 and recognizes all three isoforms of APP (immature, sAPP, and mature). This 22C11 antibody is known to cross react with APLP2.
Description & Specifications

Specifications

APP (Amyloid Precursor Protein)
Murine
Immunocytochemistry,Microscopy
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL
22C11
Alzheimer Precursor Protein A4
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer