TrkB Rabbit anti-Human, Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA118402
PA1-18402 detects Tyrosine Kinase Receptor B from human and rat samples. PA1-18402 has been successfully used in immunohistochemistry procedures. The PA1-18402 immunogen is a synthetic peptide corresponding to residues A(23) F P R L E P N S I D P E N C(36) of rat TrkB, conjugated to KLH. Reconstitute with 100 μL of distilled water.TrkB is a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). TrkB is involved in the development and maintece of the nervous system. Moreover, Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.
|whole serum with no preservative|
|Synthetic peptide corresponding to residues A(23) F P R L E P N S I D P E N C(36) of rat TrkB.|
|-20° C, Avoid Freeze/Thaw Cycles|