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anti-TIGIT, APC, Clone: 1G9, EMD Millipore™

Mouse Monoclonal Antibody

Manufacturer:  Millipore Sigma MABF1417

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Catalog No. MABF1417MI



Description

Description

Specifically detects TIGIT Clone: 1G9 in Mouse samples, and it is validated for Flow Cytometry

The 1G9 antibody reacts with mouse TIGIT (T cell Ig and ITIM domain), a 26kDa member of the CD28 receptor family which is reported to regulate T cell receptor (TCR) activation. Within the CD28 family of receptors there are those which have co-stimulatory activity, such as CD28 and CTLA-4, as well as more recently identified receptors like TIGIT which are proposed to provide co-inhibitory signals. TIGIT is expressed and upregulated on activated T cells, and is also expressed on memory and regulatory T cells. Upon engagement by its ligands, CD112 and CD155, TIGIT signaling inhibits T cell proliferation and suppresses T cell responses, without triggering cell deletion. A second inhibitory effect of TIGIT signaling is the generation of immunoregulatory dendritic cells, which secrete IL-10 and TGF-beta to further inhibit T cell function.The 1G9 antibody may be used for flow cytometric analysis of TIGIT, which is expressed at very high levels on T regulatory cells (Tregs) and activated conventional T cells, as well as memory T cells and NK cells.
Specifications

Specifications

TIGIT
1G9
Purified Mouse monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Purified
Murine
Purified by size-exclusion chromatography
RUO
2°C to 8°C for one year from date of shipment protected from light; Do not freeze
Monoclonal
Flow Cytometry
APC
P86176
Tigit
Proprietary immunogen
100μg
Inflammation, Immunology
Primary
Murine
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