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anti-TCR beta chain, APC, Clone: H57-597, EMD Millipore™

Armenian Hamster Monoclonal Antibody

Manufacturer:  Millipore Sigma MABF1453

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Catalog No. MABF1453MI



Description

Description

Specifically detects TCR beta chain Clone: H57-597 in Mouse samples, and it is validated for Flow Cytometry

The H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR). This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1+ thymocytes, NKT cells, and the majority of peripheral T cells. A small number of T cells may express an alternative heteromer of gamma and delta protein chains, known as the gamma-delta TCR. These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. The H57-597 antibody is used as a phenotypic marker for T cells expressing the alpha-beta TCR. It is also widely used to cross-link surface TCR and thereby mimic TCR-mediated cell activation or induction of apoptosis. The antibody does not cross-react with cells expressing the gamma-delta TCR.
Specifications

Specifications

TCR beta chain
H57-597
Purified Armenian Hamster monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Purified
Armenian Hamster
IgG
100μg
Inflammation, Immunology
Primary
Murine
Flow Cytometry
APC
P0C6B2
Ptcra, pT-alpha-TCR
Proprietary immunogen
Purified by size-exclusion chromatography
RUO
2°C to 8°C for one year from date of shipment protected from light; Do not freeze
Monoclonal
Documents

For Research Use Only