SPP1 Polyclonal Antibody, Invitrogen™
SPP1 Antibody, PA5-34579, from Invitrogen™. Species Reactivity: Human, Mouse, Rat; Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot.
Manufacturer: Pierce Biotechnology Inc PA534579
SPP1 Antibody, PA5-34579, from Invitrogen. Species Reactivity: Human, Mouse, Rat; Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot.The secreted protein 1 (SPP1), also known as osteopontin, is a major noncollagenous protein of bone, but is also found in the extracellular matrix of other mineralized tissues and in bodily fluids. In bone, SPP1 is produced by osteoblasts, osteocytes, macrophages, and osteoclasts. SPP1 binds to cells through integrin and non-integrin receptors, as well as the adhesion receptor CD44 in an RGD-independent manner, enabling SPP1 to induce a number of functional effects including macrophage chemotaxis, cytoprotection, and regulation of T helper type 1 cells. SPP1 can regulate biomineralization by inhibiting the formation of hydroxyapatite and the growth of calcium oxalate crystals.
Host Species: Rabbit
Cross Reactivity: Human, Mouse, Rat
Immunogen: An 18 amino acid peptide near the amino terminus of human SPP1
Formulation: 100 ug purified antibody (1mg/mL) in PBS and 0.02% sodium azide
Synonyms: SPP1, Secreted phosphoprotein 1, osteopontin, OPN, BNSP, BSPI, ETA-1
Uniprot Accession: P08721, P10451, P10923
Entrez GeneID: 20750, 25353, 6696
Gene Symbol: SPP1
A suggested positive control is human bladder tissue lysate. PA5-34579 can be used with blocking peptide PEP-1622.
|P08721, P10451, P10923|
|An 18 amino acid peptide near the amino terminus of human SPP1|
|Store at 2-8°C for up to 3 months. For long term storage store at -20°C|
|100μg purified antibody (1mg/mL) in PBS and 0.02% sodium azide|
|SPP1, Secreted phosphoprotein 1, osteopontin, OPN, BNSP, BSPI, ETA-1|
|Human, Mouse, Rat|
|20750, 25353, 6696|
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