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anti-Phospho-JAK2 pTyr221 Polyclonal, Thermo Scientific™


Phospho-JAK2 pTyr221 Polyclonal Ab PA5-35832 from Thermo Scientific™ specifically detects Phospho-JAK2 pTyr221 in Hu, Ms and Rt samples, and it is validated for WB

Manufacturer: pierce biotechnology inc  PA535832

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Catalog No. PIPA535832

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Description & Specifications

Specifications

Antigen Phospho-JAK2 pTyr221
Applications Western Blotting
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Format Purified
Formulation 100μL purified antibody (Lot-Specific) in PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No. O60674, Q62120, Q62689
Gene Alias EC 2.7.10.2, JAK-2, JAK2, Janus kinase 2, kinase Jak2
Gene Symbols JAK2
Host Species Rabbit
Immunogen Synthetic peptide derived from human JAK2 around the phosphorylation site of Tyrosine 221
Isotype IgG
Quantity 100μL
Species Reactivity Human, Mouse, Rat
Storage Requirements Store at -20°C
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Gene ID (Entrez) 16452, 24514, 3717

Phospho-JAK2 pTyr221 Polyclonal Ab PA5-35832 from Thermo Scientific™ specifically detects Phospho-JAK2 pTyr221 in Hu, Ms and Rt samples, and it is validated for WB

Janus Activating Kinase 2 (JAK2) is one of a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. However, active JAK1 may be required for complex responses. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Plays a role in leptin signaling and control of body weight.
Host Species: Rabbit
Cross Reactivity: Human, Mouse, Rat
Isotype: IgG
Immunogen: Synthetic peptide derived from human JAK2 around the phosphorylation site of Tyrosine 221
Formulation: 100μL purified antibody (Lot-Specific) in PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Synonyms: EC 2.7.10.2, JAK-2, JAK2, Janus kinase 2, kinase Jak2
Uniprot Accession: O60674, Q62120, Q62689
Entrez GeneID: 16452, 24514, 3717
Gene Symbol: JAK2
Concentration is lot-specific and will vary from 0.5-0.6 mg/ml