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anti-Parkin Polyclonal, Thermo Scientific™

Parkin Polyclonal antibody PA1-18266 from Thermo Scientific™ specifically detects Parkin in Human and Rat samples, and it is validated for Immunohistochemistry and Western Blot

$494.55 - $494.55

Specifications

Antigen Parkin
Cross Reactivity Human
Cross Reactivity Rat
Format Serum
Host Species Rabbit
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Products
Catalog Number Mfr. No. Conjugate Quantity Price Quantity    

01-670-519

 
pierce biotechnology inc
PA118266
Unlabeled 100μL Each for $494.55
Description & Specifications

Specifications

Antigen Parkin
Cross Reactivity Human
Cross Reactivity Rat
Format Serum
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues N S L I K E L H H F R I L G E E Q of human Parkin.
Isotype IgG
Monoclonal or Polyclonal Polyclonal
Primary or Secondary Primary
Storage Requirements Avoid Freeze/Thaw Cycles

Parkin Polyclonal antibody PA1-18266 from Thermo Scientific™ specifically detects Parkin in Human and Rat samples, and it is validated for Immunohistochemistry and Western Blot

Parkinson's disease is a common neurodegenerative disease with complex clinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ubiquitin-mediated proteolytic pathway by removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of Parkin. Parkin may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, and kainate-induced excitotoxicity. It may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin also regulates cyclin e during neuronal apoptosis and may represent a tumor suppressor gene.
Host Species: Rabbit
Cross Reactivity: Human, Rat
Isotype: IgG
Immunogen: Synthetic peptide corresponding to residues N S L I K E L H H F R I L G E E Q of human Parkin.
Formulation: 100μL unpurified Antibody in whole serum, with no preservative;
Synonyms: Ubiquitin E3 ligase PRKN, Parkinson juvenile disease protein 2, Parkinson disease protein 2, Prkn, Park2
Uniprot Accession: O60260, Q9JK66
Gene Symbol: PARK2
Entrez GeneID: 5071, 56816
PA1-18266 detects Parkin in Human and Rat samples. PA1-18266 has been successfully used in Immunohistochemistry and Western Blot procedures. PA1-18266 The immunogen is Synthetic peptide corresponding to residues N S L I K E L H H F R I L G E E Q of human Parkin..