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anti-NAIP Polyclonal, Thermo Scientific™


NAIP Polyclonal Ab PA5-20063 from Thermo Scientific™ specifically detects NAIP in Hu samples, and it is validated for ICC, IF and WB

Manufacturer: pierce biotechnology inc  PA520063

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Catalog No. PIPA520063

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Description & Specifications

Specifications

Formulation 100μg purified antibody (1mg/mL) in PBS and 0.02% sodium azide
Gene ID (Entrez) 4671
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Western Blot
Cross Reactivity Human
Gene Accession No. Q13075
Gene Alias BIRC1, NLRB1, psiNAIP; baculoviral IAP repeat-containing protein 1; neuronal apoptosis inhibitory protein; nucleotide-binding oligomerization domain, leucine rich repeat and BIR domain containing 1; psi neuronal apoptosis inhibitory protein
Isotype IgG
Species Reactivity Human
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Format Purified
Quantity 100μg
Storage Requirements Store at 2-8°C for up to 3 months. For long term storage store at -20°C
Host Species Rabbit
Antigen NAIP
Immunogen A synthetic peptide corresponding to 13 amino acids at the C-terminus of human NAIP.
Regulatory Status RUO
Type Primary
Classification Polyclonal
Gene Symbols NAIP
Conjugate Unlabeled

NAIP Polyclonal Ab PA5-20063 from Thermo Scientific™ specifically detects NAIP in Hu samples, and it is validated for ICC, IF and WB

Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy. Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR); these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules (reviewed in 3). Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO, suggesting that NAIP is unique among the IAPs in its regulation of its activity. Finally, although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported.
Host Species: Rabbit
Cross Reactivity: Human
Isotype: IgG
Immunogen: A synthetic peptide corresponding to 13 amino acids at the C-terminus of human NAIP.
Formulation: 100 ug purified antibody (1mg/mL) in PBS and 0.02% sodium azide
Synonyms: BIRC1, NLRB1, psiNAIP; baculoviral IAP repeat-containing protein 1; neuronal apoptosis inhibitory protein; nucleotide-binding oligomerization domain, leucine rich repeat and BIR domain containing 1; psi neuronal apoptosis inhibitory protein
Uniprot Accession: Q13075
Entrez GeneID: 4671
Gene Symbol: NAIP
A suggested positive control is PC-3 cell lysate. PA5-20063 can be used with blocking peptide PEP-0182.