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Myelin Basic Protein Polyclonal Antibody, Invitrogen™


Myelin Basic Protein Antibody, PA1-18324, from Invitrogen™. Species Reactivity: Human, Rat; Applications: Immunohistochemistry.

Manufacturer: pierce biotechnology inc  PA118324

Catalog No. 01-670-577

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Description & Specifications

Specifications

Formulation 100μL unpurified antibody in whole serum and no preservative
Immunogen Synthetic peptide corresponding to residues Y(68) G S L P Q K S Q R S Q D E N P V V(86) of guinea pig MBP, conjugated to KLH.
Applications Immunohistochemistry
Gene Symbols MBP
Gene Accession No. P02686, P02688
Species Reactivity Human, Rat
Gene Alias MBP
Gene ID (Entrez) 24547, 4155
Isotype IgG
Storage Requirements Avoid Freeze/Thaw Cycles
Format Serum
Quantity 100μL
Cross Reactivity Human
Cross Reactivity Rat
Antigen Myelin Basic Protein
Host Species Rabbit
Conjugate Unlabeled
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal

Myelin Basic Protein Antibody, PA1-18324, from Invitrogen. Species Reactivity: Human, Rat; Applications: Immunohistochemistry.

Myelin is a membrane characteristic of the nervous tissue and functions as an insulator to increase the velocity of the stimuli being transmitted between a nerve cell body and its target. Myelin isolated from human and bovine nervous tissue is composed of approximately 80% lipid and 20% protein, and 30% of the protein fraction constitutes myelin basic protein. MBP is an 'intrinsically unstructured' protein with a high proportion (approximately 75%) of random coil, but postulated to have core elements of beta-sheet and alpha-helix. MBP is a major protein in CNS myelin and is expressed specifically in the nervous system.
Host Species: Rabbit
Cross Reactivity: Human, Rat
Isotype: IgG
Immunogen: Synthetic peptide corresponding to residues Y(68) G S L P Q K S Q R S Q D E N P V V(86) of guinea pig MBP, conjugated to KLH.
Formulation: 100μL unpurified antibody in whole serum and no preservative
Synonyms: MBP
Uniprot Accession: P02686, P02688
Entrez GeneID: 24547, 4155
Gene Symbol: MBP
PA1-18324 detects MBP from human and rat samples. PA1-18324 has been successfully used in immunohistochemistry staining of MBP in abnormal oligodendrocytic process and cell bodies in demyelinating areas. This antibody recognizes only areas of myelin degeneration when tested in injured spinal cord and lesioned sciatic nerve, and also stains discrete white matter in the brain of multiple system atrophy. The PA1-18324 immunogen is a synthetic peptide corresponding to residues Y(68) G S L P Q K S Q R S Q D E N P V V(86) of guinea pig MBP, conjugated to KLH. Reconstitute with 100 ul of distilled water.