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GnRH Polyclonal Antibody, Invitrogen™

GnRH Antibody, PA1-122, from Invitrogen™. Species Reactivity: Mouse; Applications: Immunohistochemistry (Frozen).

Manufacturer:  Pierce Biotechnology Inc PA1122

Catalog No. PA1122


 

Specifications

Description

GnRH Antibody, PA1-122, from Invitrogen. Species Reactivity: Mouse; Applications: Immunohistochemistry (Frozen).

Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle.   Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.
Host Species: Rabbit
Cross Reactivity: Mouse
Isotype: IgG
Immunogen: Synthetic peptide corresponding to residues pyroE(22) H W S Y G L R P G-NH2(32) of mouse GnRH.
Formulation: 100μg purified antibody (1mg/mL) in PBS with 1mg/mL BSA and 0.05% sodium azide
Synonyms: Gonadotropin Releasing Hormone, LHRH, Luteinizing Hormone Releasing Hormone
Uniprot Accession: P13562
Entrez GeneID: 14714
Gene Symbol: GNRH1
PA1-122 detects gonadotropin releasing hormone (GnRH) in mouse brain. PA1-122 has been successfully used in immunohistochemistry procedures. Immunohistochemical staining of GnRH in newborn mouse brain tissue using PA1-122 results in neuronal staining. In immunohistochemical procedures, 4% paraformaldehyde or 2% acrolein is recommended as a fixative. The PA1-122 immunogen is a synthetic peptide corresponding to residues pyroE(22) H W S Y G L R P G-NH2(32) of mouse GnRH. This sequence is completely conserved in rat and tree shrew and is 78% conserved in zebrafish. The PA1-122 immunizing peptide (Cat. # PEP-168) is available for use in neutralization and control experiments.
References:
Test: IHC (Free), Dilution: 1:300, Species: Ms, Reference: KISS1R signals independently of Gαq/11 and triggers LH secretion via the β-arrestin pathway in the male mouse. (Nov 2014) Endocrinology, Vol: 155, 11, 4433-46, Ahow M,Min L,Pampillo M,Nash C,Wen J,Soltis K,Carroll RS,Glidewell-Kenney CA,Mellon PL,Bhattacharya M,Tobet SA,Kaiser UB,Babwah AV; Pubmed ID: 25147978
Description & Specifications

Specifications

GnRH
Unlabeled
Purified
P13562
GNRH1
Synthetic peptide corresponding to residues pyroE(22) H W S Y G L R P G-NH2(32) of mouse GnRH.
100μg
Avoid Freeze/Thaw Cycles
Polyclonal
Murine
Immunohistochemistry (Frozen)
Mouse
100μg purified antibody (1mg/mL) in PBS with 1mg/mL BSA and 0.05% sodium azide
Gonadotropin Releasing Hormone, LHRH, Luteinizing Hormone Releasing Hormone
Rabbit
IgG
Mouse
Primary
14714
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    06/30/18