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anti-PMEL17/SILV, Clone: HMB45, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP2294181ML

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 Disclaimers

For Research Use Only

Catalog No. NBP2294181M

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Description & Specifications

Specifications

Antigen PMEL17/SILV
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Clone HMB45
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Formulation Culture Medium
Gene Accession No. P40967
Host Species Mouse
Immunogen An extract of pigmented melanoma metastases from lymph nodes was used as the immunogen for the melanoma HMB45 antibody.
Isotype κ
Quantity 1mL
Regulatory Status RUO
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Gene ID (Entrez) 6490
Test Specificity By immunohistochemistry, it specifically recognizes a protein in melanocytes and melanomas. This MAb reacts with junctional and blue nevus cells and variably with fetal and neonatal melanocytes. Intradermal nevi, normal adult melanocytes, and non-melanocytic cells are negative. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin. Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas, large cell lymphomas, and sarcomas using H & E stains alone. It is also difficult to differentiate melanoma from spindle cell carcinomas and various types of mesenchymal neoplasms. Anti-HMB-45 stains fetal and neonatal melanocytes, junctional and blue nevus cells, and malignant melanoma. This MAb also stains Angiomyolipoma (PEComa). Canine (Negative), Feline (Negative).