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anti-PMEL17/SILV, Clone: HMB45, Novus Biologicals™

Manufacturer: novus biologicals canada  NBP2294181ML

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For Research Use Only

Catalog No. NBP2294181M

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Description & Specifications


Cross Reactivity Human
Antigen PMEL17/SILV
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Regulatory Status RUO
Quantity 1mL
Isotype κ
Host Species Mouse
Clone HMB45
Test Specificity By immunohistochemistry, it specifically recognizes a protein in melanocytes and melanomas. This MAb reacts with junctional and blue nevus cells and variably with fetal and neonatal melanocytes. Intradermal nevi, normal adult melanocytes, and non-melanocytic cells are negative. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin. Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas, large cell lymphomas, and sarcomas using H & E stains alone. It is also difficult to differentiate melanoma from spindle cell carcinomas and various types of mesenchymal neoplasms. Anti-HMB-45 stains fetal and neonatal melanocytes, junctional and blue nevus cells, and malignant melanoma. This MAb also stains Angiomyolipoma (PEComa). Canine (Negative), Feline (Negative).
Formulation Culture Medium
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Gene ID (Entrez) 6490
Conjugate Unlabeled
Gene Accession No. P40967
Format Concentrated
Immunogen An extract of pigmented melanoma metastases from lymph nodes was used as the immunogen for the melanoma HMB45 antibody.