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anti-p53, Clone: DO7, Novus Biologicals™

$321.00 - $429.00

Specifications

Clone DO7
Host Species Mouse
Isotype κ
Immunogen A recombinant protein fragment specific to p53 was used as immunogen for the DO7 antibody.
Antigen p53
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 Disclaimers

For Research Use Only

Products
Catalog Number Mfr. No. Conjugate Quantity Price Quantity    

NBP229419

 
novus biologicals canada
NBP229419
Unlabeled 0.5mL Each for $321.00

NBP2294191M

 
novus biologicals canada
NBP2294191ML
Unlabeled 1mL Each for $429.00
Description & Specifications

Specifications

Clone DO7
Host Species Mouse
Isotype κ
Immunogen A recombinant protein fragment specific to p53 was used as immunogen for the DO7 antibody.
Antigen p53
Monoclonal or Polyclonal Monoclonal
Format Concentrated
Primary or Secondary Primary
Regulatory Status RUO
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Test Specificity Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 37-45) of p53. Monoclonal antibody PAb1801 does not block the binding of DO-7 MAb to p53 in an ELISA test. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Gene Accession No. P04637
Gene ID (Entrez) 7157
Formulation Culture Medium