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anti-MUC-1, Clone: E29, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP229401

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 Disclaimers

For Research Use Only

Catalog No. NBP229401

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Description & Specifications

Specifications

Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Isotype λ
Clone E29
Cross Reactivity Human
Gene Accession No. P15941
Immunogen A delipidated extract of human milk fat globule membranes was used as the immunogen for the MUC-1 (EMA) E29 antibody.
Conjugate Unlabeled
Formulation Culture Medium
Primary or Secondary Primary
Gene ID (Entrez) 4582
Test Specificity In Western blotting, it recognizes proteins in MW range of 265-400kDa, identified as different glycoforms of EMA. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit and the C-terminal beta subunit. The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. EMA may provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain, which is involved in cell signaling, through phosphorylations and protein-protein interactions. In immunohistochemical assays, it superbly stains routine formalin/paraffin carcinoma tissues. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
Quantity 0.5mL
Format Concentrated
Host Species Mouse
Antigen MUC-1