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anti-MUC-1, Clone: E29, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP229401

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 Disclaimers

For Research Use Only

Catalog No. NBP229401

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Description & Specifications

Specifications

Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Regulatory Status RUO
Clone E29
Isotype λ
Cross Reactivity Human
Immunogen A delipidated extract of human milk fat globule membranes was used as the immunogen for the MUC-1 (EMA) E29 antibody.
Gene Accession No. P15941
Conjugate Unlabeled
Test Specificity In Western blotting, it recognizes proteins in MW range of 265-400kDa, identified as different glycoforms of EMA. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit and the C-terminal beta subunit. The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. EMA may provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain, which is involved in cell signaling, through phosphorylations and protein-protein interactions. In immunohistochemical assays, it superbly stains routine formalin/paraffin carcinoma tissues. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
Gene ID (Entrez) 4582
Primary or Secondary Primary
Formulation Culture Medium
Quantity 0.5mL
Host Species Mouse
Format Concentrated
Antigen MUC-1