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anti-DOG1/TMEM16A, Clone: DG1/447, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP229416

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 Disclaimers

For Research Use Only

Catalog No. NBP229416

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Description & Specifications

Specifications

Gene ID (Entrez) 55107
Format Concentrated
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Isotype κ
Host Species Mouse
Quantity 0.5mL
Antigen DOG1/TMEM16A
Gene Accession No. Q5XXA6
Formulation Culture Medium
Conjugate Unlabeled
Primary or Secondary Primary
Test Specificity Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST's), KIT signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST's, including all KIT negative GIST's. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express KIT antigen. The overall sensitivity of DOG1 and KIT in GIST's is nearly identical: 94.4% vs. 94.7%.
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Cross Reactivity Human
Immunogen A recombinant fragment specific to human DOG1 protein was used as the immunogen for the DG1/447 antibody.
Clone DG1/447