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anti-DOG1/TMEM16A, Clone: DG1/447, Novus Biologicals™

$321.00 - $429.00

Specifications

Clone DG1/447
Host Species Mouse
Isotype κ
Immunogen A recombinant fragment specific to human DOG1 protein was used as the immunogen for the DG1/447 antibody.
Antigen DOG1/TMEM16A
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 Disclaimers

For Research Use Only

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Description & Specifications

Specifications

Clone DG1/447
Host Species Mouse
Isotype κ
Immunogen A recombinant fragment specific to human DOG1 protein was used as the immunogen for the DG1/447 antibody.
Antigen DOG1/TMEM16A
Monoclonal or Polyclonal Monoclonal
Format Concentrated
Primary or Secondary Primary
Regulatory Status RUO
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Test Specificity Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST's), KIT signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST's, including all KIT negative GIST's. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express KIT antigen. The overall sensitivity of DOG1 and KIT in GIST's is nearly identical: 94.4% vs. 94.7%.
Gene Accession No. Q5XXA6
Gene ID (Entrez) 55107
Formulation Culture Medium