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anti-DOG1/TMEM16A, Clone: DG1/447, Novus Biologicals™

Manufacturer: novus biologicals canada  NBP2294161ML

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For Research Use Only

Catalog No. NBP2294161M


Description & Specifications


Antigen DOG1/TMEM16A
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Clone DG1/447
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Formulation Culture Medium
Gene Accession No. Q5XXA6
Host Species Mouse
Immunogen A recombinant fragment specific to human DOG1 protein was used as the immunogen for the DG1/447 antibody.
Isotype κ
Quantity 1mL
Regulatory Status RUO
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Gene ID (Entrez) 55107
Test Specificity Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST's), KIT signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST's, including all KIT negative GIST's. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express KIT antigen. The overall sensitivity of DOG1 and KIT in GIST's is nearly identical: 94.4% vs. 94.7%.