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anti-cleaved Retinoblastoma 1, Clone: 172C1094, Novus Biologicals™

$139.00 - $321.00

Specifications

Clone 172C1094
Host Species Mouse
Isotype IgG1
Immunogen A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb was used as immunogen.
Antigen cleaved Retinoblastoma 1
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 Disclaimers

For Research Use Only

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NB100-56598SS
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NB10056598

 
novus biologicals canada
NB100-56598
Unlabeled 0.1mg Each for $321.00
Description & Specifications

Specifications

Clone 172C1094
Host Species Mouse
Isotype IgG1
Immunogen A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb was used as immunogen.
Antigen cleaved Retinoblastoma 1
Monoclonal or Polyclonal Monoclonal
Format Purified
Primary or Secondary Primary
Regulatory Status RUO
Applications Immunohistochemistry
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Western Blotting
Test Specificity The antibody recognizes cleaved Rb (DRb-p70). The antibody does not recognize full-length Rb. In camptothecin treated HL60, an ∽68 kDa band is observed. DRb-p70 exists in vivo as an N-terminally truncated form of Rb (Liu et al.). DRb-p70 is thought to be the product of alternative translation and is expressed in primary myeloid cells in fetal liver, bone marrow and spleen. DRb-p70 is also specifically expressed in tumor-associated macrophages (TAMs). TAMs are an important targets of cancer therapy. DRb-p70 is a marker of TAMs, and maybe useful for identifying tumors with macrophage infiltration (Liu et al, 2005).
Gene ID (Entrez) 5925
Formulation PBS containing 0.05% BSA
Concentration 0.5mg/mL