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anti-cleaved Retinoblastoma 1, Clone: 172C1094, Novus Biologicals™

Manufacturer:  Novus Biologicals Canada NB10056598SS

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Catalog No. NB10056598T


 

Disclaimers:

For Research Use Only


Specifications Description & Specifications

Specifications

cleaved Retinoblastoma 1
172C1094
Unlabeled
Purified
A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb was used as immunogen.
0.025mg
Primary
5925
Human,Murine
Immunohistochemistry,Immunohistochemistry (Frozen),Immunohistochemistry (Paraffin),Western Blot
0.5mg/mL
PBS containing 0.05% BSA
Murine
IgG1
RUO
Monoclonal
The antibody recognizes cleaved Rb (DRb-p70). The antibody does not recognize full-length Rb. In camptothecin treated HL60, an ∽68 kDa band is observed. DRb-p70 exists in vivo as an N-terminally truncated form of Rb (Liu et al.). DRb-p70 is thought to be the product of alternative translation and is expressed in primary myeloid cells in fetal liver, bone marrow and spleen. DRb-p70 is also specifically expressed in tumor-associated macrophages (TAMs). TAMs are an important targets of cancer therapy. DRb-p70 is a marker of TAMs, and maybe useful for identifying tumors with macrophage infiltration (Liu et al, 2005).