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anti-cleaved Retinoblastoma 1, Clone: 172C1094, Novus Biologicals™


Manufacturer: novus biologicals canada  NB10056598SS

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 Disclaimers

For Research Use Only

Catalog No. NB10056598T

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Description & Specifications

Specifications

Test Specificity The antibody recognizes cleaved Rb (DRb-p70). The antibody does not recognize full-length Rb. In camptothecin treated HL60, an ∽68 kDa band is observed. DRb-p70 exists in vivo as an N-terminally truncated form of Rb (Liu et al.). DRb-p70 is thought to be the product of alternative translation and is expressed in primary myeloid cells in fetal liver, bone marrow and spleen. DRb-p70 is also specifically expressed in tumor-associated macrophages (TAMs). TAMs are an important targets of cancer therapy. DRb-p70 is a marker of TAMs, and maybe useful for identifying tumors with macrophage infiltration (Liu et al, 2005).
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Gene ID (Entrez) 5925
Conjugate Unlabeled
Formulation PBS containing 0.05% BSA
Concentration 0.5mg/mL
Antigen cleaved Retinoblastoma 1
Applications Immunohistochemistry
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Western Blotting
Regulatory Status RUO
Isotype IgG1
Cross Reactivity Human
Cross Reactivity Mouse
Quantity 0.025mg
Immunogen A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb was used as immunogen.
Format Purified
Host Species Mouse
Clone 172C1094