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anti-cleaved Retinoblastoma 1, Clone: 172C1094, Novus Biologicals™

Manufacturer: novus biologicals canada  NB10056598

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For Research Use Only

Catalog No. NB10056598

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Description & Specifications


Antigen cleaved Retinoblastoma 1
Applications Immunohistochemistry
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Western Blot
Clone 172C1094
Concentration 0.5mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Format Purified
Formulation PBS containing 0.05% BSA
Host Species Murine
Immunogen A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb was used as immunogen.
Isotype IgG1
Quantity 0.1mg
Regulatory Status RUO
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Gene ID (Entrez) 5925
Test Specificity The antibody recognizes cleaved Rb (DRb-p70). The antibody does not recognize full-length Rb. In camptothecin treated HL60, an ∽68 kDa band is observed. DRb-p70 exists in vivo as an N-terminally truncated form of Rb (Liu et al.). DRb-p70 is thought to be the product of alternative translation and is expressed in primary myeloid cells in fetal liver, bone marrow and spleen. DRb-p70 is also specifically expressed in tumor-associated macrophages (TAMs). TAMs are an important targets of cancer therapy. DRb-p70 is a marker of TAMs, and maybe useful for identifying tumors with macrophage infiltration (Liu et al, 2005).
Target Species Human
Target Species Murine