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anti-cleaved Retinoblastoma 1, Clone: 172C1094, Novus Biologicals™

Manufacturer: novus biologicals canada  NB10056598

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For Research Use Only

Catalog No. NB10056598

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Description & Specifications


Test Specificity The antibody recognizes cleaved Rb (DRb-p70). The antibody does not recognize full-length Rb. In camptothecin treated HL60, an ∽68 kDa band is observed. DRb-p70 exists in vivo as an N-terminally truncated form of Rb (Liu et al.). DRb-p70 is thought to be the product of alternative translation and is expressed in primary myeloid cells in fetal liver, bone marrow and spleen. DRb-p70 is also specifically expressed in tumor-associated macrophages (TAMs). TAMs are an important targets of cancer therapy. DRb-p70 is a marker of TAMs, and maybe useful for identifying tumors with macrophage infiltration (Liu et al, 2005).
Primary or Secondary Primary
Gene ID (Entrez) 5925
Conjugate Unlabeled
Formulation PBS containing 0.05% BSA
Monoclonal or Polyclonal Monoclonal
Concentration 0.5mg/mL
Isotype IgG1
Format Purified
Applications Immunohistochemistry
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Western Blotting
Antigen cleaved Retinoblastoma 1
Clone 172C1094
Immunogen A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb was used as immunogen.
Cross Reactivity Human
Cross Reactivity Mouse
Host Species Mouse
Quantity 0.1mg
Regulatory Status RUO