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anti-CD8 alpha, Clone: C8/468, Novus Biologicals™

Manufacturer: novus biologicals canada  NBP2294261ML

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For Research Use Only

Catalog No. NBP2294261M


Description & Specifications


Antigen CD8 alpha
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Clone C8/468
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Formulation Culture Medium
Gene Accession No. P01732
Host Species Mouse
Immunogen A recombinant C-terminus protein fragment specific to CD8 was used as the immunogen for the C8/468 antibody.
Isotype κ
Quantity 1mL
Regulatory Status RUO
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Gene ID (Entrez) 925
Test Specificity CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.