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anti-CD8 alpha, Clone: C8/468, Novus Biologicals™

$321.00 - $429.00

Specifications

Clone C8/468
Host Species Mouse
Isotype κ
Immunogen A recombinant C-terminus protein fragment specific to CD8 was used as the immunogen for the C8/468 antibody.
Antigen CD8 alpha
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 Disclaimers

For Research Use Only

Products
Catalog Number Mfr. No. Conjugate Quantity Price Quantity    

NBP229426

 
novus biologicals canada
NBP229426
Unlabeled 0.5mL Each for $321.00

NBP2294261M

 
novus biologicals canada
NBP2294261ML
Unlabeled 1mL Each for $429.00
Description & Specifications

Specifications

Clone C8/468
Host Species Mouse
Isotype κ
Immunogen A recombinant C-terminus protein fragment specific to CD8 was used as the immunogen for the C8/468 antibody.
Antigen CD8 alpha
Monoclonal or Polyclonal Monoclonal
Format Concentrated
Primary or Secondary Primary
Regulatory Status RUO
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Test Specificity CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.
Gene Accession No. P01732
Gene ID (Entrez) 925
Formulation Culture Medium