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anti-CD63, Clone: NKI/C3, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP2328291ML

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 Disclaimers

For Research Use Only

Catalog No. NBP2328291M

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Description & Specifications

Specifications

Host Species Mouse
Applications ELISA
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Immunogen Smooth plasma membrane fraction of MeWo cells
Regulatory Status RUO
Clone NKI/C3
Isotype κ
Format Purified
Quantity 1mL
Antigen CD63
Cross Reactivity Human
Cross Reactivity Mouse
Conjugate Unlabeled
Formulation PBS with 0.05% BSA.
Gene ID (Entrez) 967
Concentration 0.2mg/mL
Test Specificity This MAb recognizes protein of 26kDa-60kDa, which is identified as CD63. Its epitope is different from that of MAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
Monoclonal or Polyclonal Monoclonal
Gene Accession No. P08962
Primary or Secondary Primary