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anti-CD5, Clone: C5/473, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP229436

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 Disclaimers

For Research Use Only

Catalog No. NBP229436

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Description & Specifications

Specifications

Antigen CD5
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Clone C5/473
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Formulation Culture Medium
Gene Accession No. P06127
Host Species Mouse
Immunogen A recombinant fragment specific to human CD5 protein was used as the immunogen for the C5/473 antibody.
Isotype κ
Quantity 0.5mL
Regulatory Status RUO
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Gene ID (Entrez) 921
Test Specificity Recognizes a 67kDa transmembrane protein, which is identified as CD5. The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (∽10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms. Anti-CD5 detection is diagnostic in CLL/SLL within a panel of other B-cell markers, especially one that includes anti-CD23. Anti-CD5 is also very useful in differentiating among mature small lymphoid cell malignancies. In addition, anti-CD5 can be used in distinguishing thymic carcinoma (+) from thymoma (-). Anti-CD5 does not react with granulocytes or monocytes.