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anti-CD5, Clone: C5/473, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP2294361ML

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 Disclaimers

For Research Use Only

Catalog No. NBP2294361M

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Description & Specifications

Specifications

Antigen CD5
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Isotype κ
Clone C5/473
Host Species Mouse
Format Concentrated
Cross Reactivity Human
Immunogen A recombinant fragment specific to human CD5 protein was used as the immunogen for the C5/473 antibody.
Regulatory Status RUO
Conjugate Unlabeled
Gene Accession No. P06127
Primary or Secondary Primary
Gene ID (Entrez) 921
Formulation Culture Medium
Quantity 1mL
Monoclonal or Polyclonal Monoclonal
Test Specificity Recognizes a 67kDa transmembrane protein, which is identified as CD5. The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (∽10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms. Anti-CD5 detection is diagnostic in CLL/SLL within a panel of other B-cell markers, especially one that includes anti-CD23. Anti-CD5 is also very useful in differentiating among mature small lymphoid cell malignancies. In addition, anti-CD5 can be used in distinguishing thymic carcinoma (+) from thymoma (-). Anti-CD5 does not react with granulocytes or monocytes.