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anti-CD45RB, Clone: PD7/26, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP229632

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 Disclaimers

For Research Use Only

Catalog No. NBP229632

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Description & Specifications

Specifications

Antigen CD45RB
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Clone PD7/26
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Formulation Culture Medium
Gene Accession No. P08575
Host Species Mouse
Immunogen Human peripheral blood lymphocytes maintained in T-cell growth factor was used as the immunogen for the CD45RB PD7/26 antibody.
Isotype κ
Quantity 0.5mL
Regulatory Status RUO
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Gene ID (Entrez) 5788
Test Specificity CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.