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anti-Ly-6G FITC, Clone: RB6-8C5, EMD Millipore™

Rat Monoclonal Antibody

Manufacturer:  Millipore Sigma MABF1481

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Catalog No. MABF1481MI



Description

Description

Specifically detects Ly-6G Clone: RB6-8C5 in Mouse samples, and it is validated for Flow Cytometry

The RB6-8C5 antibody binds to mouse Ly-6G, commonly known as Gr-1, a member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. Gr-1 is differentially expressed during development and maturation of cells in the myeloid lineage and is expression at varying stages and levels on monocytes, macrophages, granulocytes, and peripheral neutrophils. In the mouse, the RB6-8C5 antibody is typically used in combination with the macrophage labeling antibody M1/70 (Anti-CD11b) for phenotypic analysis of monocytes, macrophages and granulocytes.Note: The RB6-8C5 antibody has been reported to cross-react with Ly-6C on cells expressing this antigen (Fleming et al. 1993. J. Immunol. 151:2399-2408 and Sasmono et al. 2007. J. Leukoc. Biol. 82: 111-123) and has been cited in the literature for identification of Ly-6G/Ly-6C. Other reports suggest that this antibody is specific for Ly-6G, without cross-reactivity for Ly-6C (Nagendra S. and Schlueter AJ. 2003. Cytometry A, 58(2): 195-200.
Specifications

Specifications

Ly-6G
RB6-8C5
Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Purified
Rat
Purified by size-exclusion chromatography
RUO
2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Monoclonal
Flow Cytometry
FITC
P35461
Ly6g
Proprietary immunogen
25μg
Inflammation, Immunology
Primary
Murine
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For Research Use Only